HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.
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چکیده
منابع مشابه
Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles.
Certain HLA-DR alleles confer strong susceptibility to the autoimmune disease rheumatoid arthritis (RA). We compared RA-associated alleles, HLA-DR*0401, HLA-DR*0404, and HLA-DR*0405, with closely related, non-RA-associated alleles, HLA-DR*0402 and HLA-DR*0403, to determine whether they differ in their interactions with the class II chaperone, invariant chain (Ii). Ii binds to class II molecules...
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Letters Cigarette smoking, Parkinson's disease and ulcerative colitis Sir: Individuals who develop Parkinson's disease are about twice as likely to have been habitual non-smokers when compared with a control population.`1 Smoking also seems to exert considerable protective effects against ulcerative colitis.46 It has been suggested that both these illnesses may be associated with inflexible, mo...
متن کاملHLA-DR alleles among Pakistani patients of coeliac disease.
OBJECTIVES To investigate whether certain DR alleles might also contribute to the genetic susceptibility among Coeliac disease patients in Pakistan. METHODS The case-control study was conducted at the Military Hospital, Rawalpindi, from October 2011 to January 2012, and analysed 25 children diagnosed to have coeliac disease as per the criteria set by the European Society of Paediatric Gastroe...
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OBJECTIVE To determine frequency of HLA-DR alleles in Pakistani patients of pemphigus vulgaris in comparison with local healthy controls. STUDY DESIGN Cross-sectional, comparative study. PLACE AND DURATION OF STUDY Department of Immunology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, from January 2011 to January 2014. METHODOLOGY Twenty eight patients with biopsy proven diagno...
متن کاملRedundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.
The three HLA class II alleles of the DR2 haplotype, DRB1*1501, DRB5*0101, and DQB1*0602, are in strong linkage disequilibrium and confer most of the genetic risk to multiple sclerosis. Functional redundancy in Ag presentation by these class II molecules would allow recognition by a single TCR of identical peptides with the different restriction elements, facilitating T cell activation and prov...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1987
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.84.13.4591